[HTML][HTML] 3D in vitro human organ mimicry devices for drug discovery, development, and assessment

A Rodriguez-Garcia, J Oliva-Ramirez… - Advances in Polymer …, 2020 - hindawi.com
… CYP3A1 and CYP2C11 Rat hepatocyte primary cell culture … When acetaminophen and
amiodarone were introduced into … the exchange of oxygen and carbon dioxide occurs. The main …

Drug‐Metabolizing Enzymes and Drug Toxicity

AP Li - Transporters and Drug‐Metabolizing Enzymes in Drug …, 2021 - Wiley Online Library
… Inhibition of ALDH by carbon tetrachloride is reported to be a … Interaction of amiodarone
with racemic warfarin and its … isolated rat hepatocytes. Drug Res (Stuttg) 2016;66(11):592–96. …

Interplay between Drug-Induced Liver Injury and Gut Microbiota: A Comprehensive Overview

G Li, Y Hou, C Zhang, X Zhou, F Bao, Y Yang… - Cellular and Molecular … - cmghjournal.org
studies to inhibit the expression of inflammatory factors, alleviate oxidative stress, and markedly
mitigate liver injury induced by carbon tetrachloride.… drug interactions between lovastatin

[HTML][HTML] The hepatic lipidome: From basic science to clinical translation

M Ten Hove, L Pater, G Storm, S Weiskirchen… - Advanced drug delivery …, 2020 - Elsevier
… -CoA is oxidized into water and carbon dioxide (CO 2 ), and … still unknown, recent research
reported the interaction between two … Furthermore, lipid accumulation in hepatocytes acts as …

Metabolomics-based strategy to assess drug hepatotoxicity and uncover the mechanisms of hepatotoxicity involved

T Martínez-Sena, E Moro, M Moreno-Torres… - Archives of …, 2023 - Springer
… The use of in vitro models and particularly cultured hepatocytes represents an easy and
robust alternative to animal drug hepatotoxicity testing for predicting human risk. Here, we …

Influence of xenobiotic substance on hepatic co-cultures

F Padberg - 2021 - refubium.fu-berlin.de
… primary rat hepatocytes dedifferentiate within three days [70]. Concerning human primary
hepatocytes, co-… Finally, these interactions will be compared with the previously established …

[PDF][PDF] Development of an in vitro test battery for a test system to predict human drug-induced liver injury

T Brecklinghaus - 2021 - eldorado.tu-dortmund.de
vitro using a cytotoxicity test (CTB assay) with primary human hepatocytes (PHH) and
comparison to in vivo … In this PhD-thesis, I studied whether extending the in vitro test battery, so far …

Completion of the DrugMatrix Toxicogenomics Database using ToxCompl

G Cong, RM Patton, F Chao, DL Svoboda, WM Casey… - bioRxiv, 2024 - biorxiv.org
… Rather than modeling the interaction between treatments … treatments lovastatin-1500mg/kg-5
day (measured) to lovastatin… ,n-dimethylformamide, and carbon tetrachloride (see Complete …

Role of Pharmacoproteomics

KK Jain, KK Jain - Textbook of Personalized Medicine, 2021 - Springer
… Proteomics is an important component of several interactingLovastatin treatment is
associated with signs of toxicity as … , amiodarone, tetracycline and carbon tetrachloride) that are …

Impact of Maternal Th-17 Associated Inflammatory Disease on the Expression of Placental Transporters

K Mirdamadi - tspace.library.utoronto.ca
… Numerous in-vitro and in-vivo studies have demonstrated that inflammation such as
bacterial or viral infections impact the regulation of placental PGP. Exposure of first trimester …